Editorial | Masters of Longevity

Conceptual amber glass heart within a translucent teal torso, illustrating an organ within its surrounding body.

MoL Science Brief • 05 Oct 2026 • 3 min readHow Old Is a Transplanted Heart?By Marcel AchermannA small human study suggests that a donor heart’s molecular age responds to its new host. What does that tell us about ageing?Ageing biologyHeart transplantationScience

Conceptual biomedical lab scene with AI research-agent panels connecting literature, hypothesis planning and experiment analysis to an automated pipetting station and a scientist at a microscope; not experimental data.

MoL Commentary • 24 Sept 2026 • 5 min readAnthropic’s Claude Phage Finding and the New Pace of ResearchBy Marcel AchermannAI is moving from prediction to research loops that search, propose and learn from experiments. Claude's discovery of a CRISPR-like enzyme system hints at how much faster discovery could become.AI in biologyBiotechnologyGenome discovery

Three global-health professionals examine a city map and interconnected images of neighbourhoods, services and care settings in a research workspace.

MoL Science Brief • 24 Sept 2026 • 4 min readWhat Global Dementia Risk Models Still MissBy Marcel AchermannA 2025 Personal View argues that poverty, wealth shocks, income inequality and HIV belong in dementia prevention models. The direction is persuasive. The 65% figure is not yet a prevention result.DementiaPreventionGlobal health

Older woman practising a controlled heel-to-toe balance step beside a sturdy chair at home, with a small unbranded supplement jar on a side table.

MoL Science Brief • 22 Sept 2026 • 4 min readCalcium, Vitamin D and Fall Prevention: What the Evidence ChangesBy Marcel AchermannAcross 69 randomized trials, routine calcium or vitamin D supplements did little to prevent fractures or falls. The useful question is where targeted care can do better.Healthy ageingBone healthFall prevention

Conceptual cross-section of human hippocampal tissue with support cells, microglia-like cells and folded chromatin inside a cell nucleus.

MoL Editorial • 20 Sept 2026 • 3 min readWhat Changes in the Human Hippocampus with Age?By Marcel AchermannA study of 40 postmortem brains maps a midlife shift in immune cells and a wider loss of cellular and genome organisation—but it does not show how to prevent cognitive decline.ScienceBrain healthAgeing biology

A hand removes one bright red block from an elaborate tower of supplements, wearables and diagnostic devices, revealing a clear illuminated path.

MoL Editorial • 18 Sept 2026 • 8 min readThe Most Important Longevity Intervention May Be SubtractionBy Masters of LongevityLongevity advice almost always asks what to add things. A disciplined subtraction audit can reduce risk, recover attention and reveal which parts of a health routine are actually earning their place.Longevity StrategySupplementsDiagnostics

Conceptual glass DNA helix and separate building blocks in a dark laboratory-inspired scene.

MoL Editorial • 17 Sept 2026 • 8 min readNucleotides and Longevity: Is the Evidence Ready?By Marcel AchermannThey help build DNA and keep cells working. Early human studies make nucleotide supplements interesting—but leave important questions about healthy ageing unanswered. Yet.SupplementsHealthy ageingNutrition

Conceptual close-up of a translucent ageing cell with a blue nucleus and bright amber mitochondria in a deep teal tissue environment.

MoL Editorial • 15 Sept 2026 • 3 min readReducing Inflammation from Ageing Cells: What a Mouse Study FoundBy Marcel AchermannResearchers reduced the inflammatory signals released by cells that had stopped dividing. Older mice also improved on some strength and frailty tests. Whether this approach could help people remains unknown.Ageing biologyCellular senescenceInflammation

A centrally balanced bedside still life with an amber bottle labelled MELATONIN, two tablets and a glass of water.

MoL Editorial • 14 Sept 2026 • 6 min readMelatonin and Heart Failure: What the Evidence Actually ShowsBy Marcel AchermannA 2025 study linked melatonin use with heart failure. A 2026 analysis found no significant association. Their different designs explain why the question remains open.SleepMelatoninHeart health

Apple Health results overview and Apple Watch Series 12 against a flowing health-data background.

MoL Editorial • 12 Sept 2026 • 4 min readApple Brings Longevity to the Wrist. What Will It Change?By Marcel AchermannApple’s new Health Age, readiness and movement tools bring long-term health into everyday view. The opportunity is turning that information into useful action.WearablesHealthy agingApple Health

An older woman practices a controlled side-step in her living room while a physiotherapist stands nearby.

MoL Editorial • 11 Sept 2026 • 5 min readCan Exergaming Improve Balance? What Older Adults Should KnowBy Marcel AchermannMotion-controlled games may make balance practice easier to repeat. The evidence supports a structured adjunct—not a fall-proofing shortcut.Healthy ageingExerciseFall prevention

Conceptual bronze and smoked-glass hourglass on a dark textured surface, illustrating intervention timing.

MoL Editorial • 10 Sept 2026 • 2 min readGrowth Hormone Receptor Deletion Extends Mouse LifespanBy Marcel AchermannStudy summary: researchers switched off the growth hormone receptor in middle-aged mice and followed survival and physical function.ScienceAgeing biologyGrowth hormone

A glass carafe of golden cooking oil beside soybeans on a dark stone kitchen surface.

MoL Editorial • 09 Sept 2026 • 7 min readSeed Oils and Health: Inflammation, Processing and EvidenceBy Marcel AchermannHuman trials, processing risks and long-term health ask different questions. What can seed-oil research tell us—and what remains unresolved?NutritionScientific evidenceInflammation

A health-planning workspace with a smartphone, diagnostic measurements and a structured report.

MoL Editorial • 08 Sept 2026 • 3 min readPlan Your Health Tests in Three MinutesBy Masters of LongevityThe free Personal Health Diagnostics Planner turns a short questionnaire into a ranked, personalised PDF: a clearer starting point for deciding which health checks deserve attention now.Preventive HealthDiagnosticsPersonal Health

Conceptual editorial illustration of an upright laboratory mouse beside an unbranded injection pen on a dark stone surface.

MoL Editorial • 08 Sept 2026 • 6 min readSemaglutide Extended Lifespan in Mice. What Would Make It a Human Longevity Drug?By Marcel AchermannA new animal study sharpens an important question: when do benefits in a particular disease become evidence for a longer, healthier life?ScienceHealthy ageingGLP-1

The Royal National Academy of Medicine of Spain in Madrid, venue of the International Longevity Summit 2026.

MoL Event • 01 Sept 2026 • 5 min readInternational Longevity Summit Madrid 2026By Masters of LongevityScientists, clinicians, founders and investors meet in Madrid on 30 September and 1 October for two days spanning ageing biology, preventive medicine, AI, biomarkers, biotechnology and the longevity economy.EventsLongevity ScienceMadrid

A blood sample tube centred on a biological-age dial with lifespan rings, biomarker nodes, and molecular patterns.

MoL Editorial • 31 Aug 2026 • 9 min readCan You Really Measure Whether You’re Aging More Slowly?By Marcel AchermannA younger epigenetic-age score can look like proof that an intervention is working. A major new analysis shows which clocks detect change—and why movement is not yet the same as longer healthspan.Biological AgeDiagnosticsLongevity Science

An unbranded jar of creatine powder beside abstract immune-cell and circulating-cell laboratory image plates.

MoL Editorial • 27 Aug 2026 • 9 min readCreatine and Cancer: Why New Mouse Studies Point in Opposite DirectionsBy Masters of LongevityCreatine strengthened antitumour immune cells in one mouse study—and promoted metastasis through platelets in another. The apparent contradiction reveals why neither result is a supplement recommendation.CreatineCancer ResearchSupplements