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Masters of Longevity - The Pulse

Feature31 Aug 2026

Can You Really Measure Whether You’re Aging More Slowly?

A younger epigenetic-age score can look like proof that an intervention is working. A major new analysis shows which clocks detect change—and why movement is not yet the same as longer healthspan.

A blood sample tube centred on a biological-age dial with lifespan rings, biomarker nodes, and molecular patterns.

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Based on last 48h engagement

  1. 01Semaglutide Extended Lifespan in Mice. What Would Make It a Human Longevity Drug? (Masters of Longevity)Semaglutide Extended Lifespan in Mice. What Would Make It a Human Longevity Drug?Masters of Longevity • 08 Sept 2026
  2. 02International Longevity Summit Madrid 2026 (Masters of Longevity)International Longevity Summit Madrid 2026Masters of Longevity • 01 Sept 2026
  3. 03Spatially guided in vivo single-cell functional genomics of postnatal heart (Nature - Biotechnology)Spatially guided in vivo single-cell functional genomics of postnatal heartNature - Biotechnology • 07 Sept 2026
  4. 04Fractyl Health’s Revita data show lasting weight loss (Longevity Technology)Fractyl Health’s Revita data show lasting weight lossLongevity Technology • 01 Sept 2026
  5. 05Adjunctive traditional Chinese medicine for ischemic stroke: a systematic review with structured narrative synthesis and GRADE assessment o... (Frontiers - Hea...Adjunctive traditional Chinese medicine for ischemic stroke: a systematic review with structured narrative synthesis and GRADE assessment of randomized controlled trialsFrontiers - Health • 04 Sept 2026

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  1. Category Summit Longevity (New York, United States)8. SEPT 2026 - 9. SEPT 2026Category Summit LongevitySummit - New York, USA
  2. 75th Annual Scientific Meeting of the BSRA: The Biology of Ageing (Oxford, United Kingdom)9. SEPT 2026 - 11. SEPT 202675th Annual Scientific Meeting of the BSRA: The Biology of AgeingConference - Oxford, UK
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  5. International Longevity Summit Madrid 2026 (Madrid, Spain)28. SEPT 2026 - 1. OCT 2026International Longevity Summit Madrid 2026Summit - Madrid, Spain★

Latest in Longevity

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Nature - Biotechnology09 Sept 2026
AIPopulation structure and genetic diversity of cowpea germplasm from Senegal within a global framework (Nature - Biotechnology)

Population structure and genetic diversity of cowpea germplasm from Senegal within a global framework

Genetic diversity and population structure of Senegalese cowpea germplasm are examined within a global context, offering insights for breeders and researchers.

Key takeaways
  • Senegalese cultivated cowpea accessions showed genetic diversity ranked among the highest across global minicore subpopulations.
  • Population analysis recovered six global clusters and identified three additional groups unique to the Senegalese collection.
  • Wild Senegalese accessions formed a distinct and genetically homogeneous cluster separate from cultivated types.
Longevity Technology08 Sept 2026
Rznomics brings RNA editing into Lilly’s San Diego biotech hub (Longevity Technology)

Rznomics brings RNA editing into Lilly’s San Diego biotech hub

A South Korean RNA-editing company has taken lab space inside a major pharma's San Diego innovation hub to accelerate its US clinical and partnership efforts.

Key takeaways
  • Rznomics joined Lilly Gateway Labs in San Diego to gain wet-lab access and proximity to Lilly scientists.
  • Rznomics previously signed a collaboration and licensing deal with Eli Lilly on an RNA-editing therapeutic.
  • Rznomics develops trans-splicing ribozymes and is advancing oncology and rare disease candidates toward clinical work.
PR Newswire08 Sept 2026
Cell Stem Cell: Die tBE-vermittelte Base-Editing-Therapie erzielt bei unterschiedlichen genetischen Hintergründen eine dauerhafte klinische Remission bei Sichel

Cell Stem Cell: Die tBE-vermittelte Base-Editing-Therapie erzielt bei unterschiedlichen genetischen Hintergründen eine dauerhafte klinische Remission bei Sichelzellkrankheit und β-Thalassämie

Reports clinical results showing a transformer Base Editor (tBE) autologous HSPC therapy induced durable remission across diverse β-hemoglobinopathy genotypes, including sickle cell disease and transfusion-dependent β-thalassemia.

Key takeaways
  • All four non-Chinese patients treated with CS-101/CS-206 achieved durable clinical remission without transfusions or vaso-occlusive crises.
  • TBE produced rapid hematopoietic engraftment with neutrophil recovery at day 13 and platelet recovery at day 21 in the SCD patient.
  • No off-target edits or product-related adverse events were detected across treated patients during median follow-up of ~16–18 months.
Longevity Technology08 Sept 2026
Rentosertib puts aging clocks to the clinical test (Longevity Technology)

Rentosertib puts aging clocks to the clinical test

A clinical-research feature about applying multiple proteomic aging clocks to trial samples to assess whether a drug shows geroprotection signals. Read on for a perspective piece that weighs methodological strengths, ambiguities, and next steps for translating such dual-purpose trials into convincing aging science.

Key takeaways
  • The strongest and most consistent clock responses occurred at week four with the 30 mg twice-daily regimen, where five of six clocks showed negative effect sizes.
  • Changes in forced vital capacity explained little of the variance in predicted biological age, with a median R² of 0.06 across the six clocks.
  • Six distinct proteomic aging clocks all detected treatment-associated reductions in predicted biological age after rentosertib dosing.
MoL Event Pick
International Longevity Summit Madrid 2026 (Madrid, Spain)

International Longevity Summit Madrid 2026

28. SEPT 2026 - 1. OCT 2026 - Madrid, SpainSummit

Madrid summit convening global longevity thinkers, clinicians and innovators across four days of science, networking and public-facing programming.

Register