Editorial | Masters of Longevity

Conceptual cross-section of human hippocampal tissue with support cells, microglia-like cells and folded chromatin inside a cell nucleus.

MoL Editorial • 20 Sept 2026 • 3 min readWhat Changes in the Human Hippocampus with Age?By Marcel AchermannA study of 40 postmortem brains maps a midlife shift in immune cells and a wider loss of cellular and genome organisation—but it does not show how to prevent cognitive decline.ScienceBrain healthAgeing biology

A hand removes one bright red block from an elaborate tower of supplements, wearables and diagnostic devices, revealing a clear illuminated path.

MoL Editorial • 18 Sept 2026 • 8 min readThe Most Important Longevity Intervention May Be SubtractionBy Masters of LongevityLongevity advice almost always asks what to add things. A disciplined subtraction audit can reduce risk, recover attention and reveal which parts of a health routine are actually earning their place.Longevity StrategySupplementsDiagnostics

Conceptual glass DNA helix and separate building blocks in a dark laboratory-inspired scene.

MoL Editorial • 17 Sept 2026 • 8 min readNucleotides and Longevity: Is the Evidence Ready?By Marcel AchermannThey help build DNA and keep cells working. Early human studies make nucleotide supplements interesting—but leave important questions about healthy ageing unanswered. Yet.SupplementsHealthy ageingNutrition

Conceptual close-up of a translucent ageing cell with a blue nucleus and bright amber mitochondria in a deep teal tissue environment.

MoL Editorial • 15 Sept 2026 • 3 min readReducing Inflammation from Ageing Cells: What a Mouse Study FoundBy Marcel AchermannResearchers reduced the inflammatory signals released by cells that had stopped dividing. Older mice also improved on some strength and frailty tests. Whether this approach could help people remains unknown.Ageing biologyCellular senescenceInflammation

A centrally balanced bedside still life with an amber bottle labelled MELATONIN, two tablets and a glass of water.

MoL Editorial • 14 Sept 2026 • 6 min readMelatonin and Heart Failure: What the Evidence Actually ShowsBy Marcel AchermannA 2025 study linked melatonin use with heart failure. A 2026 analysis found no significant association. Their different designs explain why the question remains open.SleepMelatoninHeart health

Apple Health results overview and Apple Watch Series 12 against a flowing health-data background.

MoL Editorial • 12 Sept 2026 • 4 min readApple Brings Longevity to the Wrist. What Will It Change?By Marcel AchermannApple’s new Health Age, readiness and movement tools bring long-term health into everyday view. The opportunity is turning that information into useful action.WearablesHealthy agingApple Health

An older woman practices a controlled side-step in her living room while a physiotherapist stands nearby.

MoL Editorial • 11 Sept 2026 • 5 min readCan Exergaming Improve Balance? What Older Adults Should KnowBy Marcel AchermannMotion-controlled games may make balance practice easier to repeat. The evidence supports a structured adjunct—not a fall-proofing shortcut.Healthy ageingExerciseFall prevention

Conceptual bronze and smoked-glass hourglass on a dark textured surface, illustrating intervention timing.

MoL Editorial • 10 Sept 2026 • 2 min readGrowth Hormone Receptor Deletion Extends Mouse LifespanBy Marcel AchermannStudy summary: researchers switched off the growth hormone receptor in middle-aged mice and followed survival and physical function.ScienceAgeing biologyGrowth hormone

A glass carafe of golden cooking oil beside soybeans on a dark stone kitchen surface.

MoL Editorial • 09 Sept 2026 • 7 min readSeed Oils and Health: Inflammation, Processing and EvidenceBy Marcel AchermannHuman trials, processing risks and long-term health ask different questions. What can seed-oil research tell us—and what remains unresolved?NutritionScientific evidenceInflammation

A health-planning workspace with a smartphone, diagnostic measurements and a structured report.

MoL Editorial • 08 Sept 2026 • 3 min readPlan Your Health Tests in Three MinutesBy Masters of LongevityThe free Personal Health Diagnostics Planner turns a short questionnaire into a ranked, personalised PDF: a clearer starting point for deciding which health checks deserve attention now.Preventive HealthDiagnosticsPersonal Health

Conceptual editorial illustration of an upright laboratory mouse beside an unbranded injection pen on a dark stone surface.

MoL Editorial • 08 Sept 2026 • 6 min readSemaglutide Extended Lifespan in Mice. What Would Make It a Human Longevity Drug?By Marcel AchermannA new animal study sharpens an important question: when do benefits in a particular disease become evidence for a longer, healthier life?ScienceHealthy ageingGLP-1

A blood sample tube centred on a biological-age dial with lifespan rings, biomarker nodes, and molecular patterns.

MoL Editorial • 31 Aug 2026 • 9 min readCan You Really Measure Whether You’re Aging More Slowly?By Marcel AchermannA younger epigenetic-age score can look like proof that an intervention is working. A major new analysis shows which clocks detect change—and why movement is not yet the same as longer healthspan.Biological AgeDiagnosticsLongevity Science

An unbranded jar of creatine powder beside abstract immune-cell and circulating-cell laboratory image plates.

MoL Editorial • 27 Aug 2026 • 9 min readCreatine and Cancer: Why New Mouse Studies Point in Opposite DirectionsBy Masters of LongevityCreatine strengthened antitumour immune cells in one mouse study—and promoted metastasis through platelets in another. The apparent contradiction reveals why neither result is a supplement recommendation.CreatineCancer ResearchSupplements

An unbranded supplement bottle, capsules and a blood sample grouped on the right beside laboratory results.

MoL Editorial • 25 Aug 2026 • 6 min readBiotin for Hair Growth: The Weak Evidence—and the Blood-Test Risk Most People MissBy Masters of LongevityBiotin deficiency can affect hair. That does not mean more biotin makes healthy hair grow—and high doses can distort important laboratory results.SupplementsHair HealthDiagnostics

A physician discussing evidence-based preventive care with an older patient in a consultation room

MoL Editorial • 24 Jul 2026 • 4 min readCan Doctors Be Trained for the Longevity Era?By Marcel AchermannA new global survey suggests that healthy longevity medicine education can change how physicians think and talk about ageing. But the evidence also highlights how much work remains before a rapidly growing field becomes routine clinical care.Longevity medicineMedical educationGeroscience

ApoB

MoL Editorial • 07 Jul 2026 • 6 min readApoB: The cholesterol signal LDL can missBy Marcel AchermannIn longevity medicine, the useful biomarkers are not always the exotic ones. ApoB is a relatively simple blood test that can sharpen cardiovascular prevention when LDL-C looks reassuring but particle burden remains high.ApoBCardiovascular riskCholesterol

Unlabeled biologic vials in front of body-composition scan imagery

MoL Editorial • 25 Jun 2026 • 7 min readThe Next Obesity-Drug Race Is About What Weight You LoseBy Marcel AchermannRegeneron’s myostatin and activin A antibodies point to a sharper question for the GLP-1 era: not whether people can lose more weight, but whether medicine can preserve the tissue that makes weight loss healthier.Regeneron PharmaceuticalsMyostatin inhibitorsActivin A inhibitors

From Metrics to Better Living

MoL Editorial • 06 May 2026 • 7 min readFrom Metrics to Better LivingBy Marcel AchermannEverstride’s May 2026 Consumer Health Market Briefing shows a wellness market moving from products to systems, from tracking to guidance, and from optimization to meaning. The next winners in longevity may not be the companies that measure the most. They may be the ones that help consumers translate health data into a life they actually want to live.Market viewEverstride