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Nomogram integrating BRAF V600E, serum biomarkers, and ultrasound features for malignancy risk stratification in C-TIRADS category 3 and 4 thyroid nodules

Source: Frontiers - Health • Published: 27 Aug 2026, 00:00

Nomogram integrating BRAF V600E, serum biomarkers, and ultrasound features for malignancy risk stratification in C-TIRADS category 3 and 4 thyroid nodules

A retrospective study develops a nomogram combining BRAF V600E, serum biomarkers, and ultrasound features to stratify malignancy risk in C-TIRADS 3 and 4 thyroid nodules.

Key Takeaways
  • Although only about 5–15% of nodules found on ultrasound are cancerous ( 2 )
  • Ultrasound serves as the first-line tool when a thyroid lump is suspected
  • However, their malignancy risk varies widely, from 2 to 90% ( 3 ), and their optimal management is still debated
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