Heritable transgenic schistosomes that secrete a therapeutic antibody fragment in vivo — a research article describing a living-platform approach for sustained protein delivery.
Key Takeaways
- Researchers generated the first heritable transgenic Schistosoma mansoni line with chromosomal transgene insertion
- Transgenic worms secreted a VHH–IgG1 Fc (C5-Fc) antibody fragment into mouse circulation systemically
- Sera from mice carrying C5-Fc worms neutralized SARS-CoV-2 in vitro consistent with ACE2-blocking activity