Longevity News

A fully human afucosylated anti-GARP antibody PBA-0111 drives anti-tumor immunity through combined ADCC induction and TGF-β1 pathway blockade

Source: Frontiers - Health • Published: 24 Aug 2026, 00:00

A fully human afucosylated anti-GARP antibody PBA-0111 drives anti-tumor immunity through combined ADCC induction and TGF-β1 pathway blockade

Report on a dual-action human afucosylated anti-GARP antibody that combines ADCC induction with blockade of TGF-β1 activation to boost anti-tumor immunity.

Key Takeaways
  • Presage Biosciences, Inc., Seattle, WA, United States The final, formatted version of the article will be published soon
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  • PBA-0111 was compared with clinically tested anti-GARP antibodies, including DS-1055a- and ABBV-151- like antibodies
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