Examines how an anti-CD6 monoclonal antibody triggers CD6 internalization and alters costimulatory receptor availability to reshape CD4+ T-cell activation.
Key Takeaways
- Best-characterized ligand of CD6 is activated leukocyte cell adhesion molecule (ALCAM/CD166)
- CD6 has been linked to the regulation of T-cell activation thresholds ( 14 )
- Both genetic deletion of CD6 and treatment of CD6-humanized mice with UMCD6