Masters of Longevity - The Pulse

Nature - Main01 Jun 2026
Obesity doesn’t equate to ill health: why the ‘disease’ label doesn’t always fit (Nature - Main)

Obesity doesn’t equate to ill health: why the ‘disease’ label doesn’t always fit

Obesity receives a thoughtful, evidence-informed commentary exploring nuanced perspectives on stigma and how medical framing shapes care and policy.

Key takeaways
  • 56-expert international commission convened by The Lancet proposed clinical and preclinical obesity.
  • Seventy-six medical organizations worldwide endorsed the commission's proposed classification.
  • Some specialist societies argue the distinction could complicate diagnosis and restrict treatments.
Frontiers - Health01 Jun 2026
AIA feedback loop sustaining neutrophil extracellular trap formation involves S100 proteins, histones, TLR2 and RAGE, and is restrained by albumin (Frontiers - He

A feedback loop sustaining neutrophil extracellular trap formation involves S100 proteins, histones, TLR2 and RAGE, and is restrained by albumin

Learn about a newly described immune feedback loop that sustains neutrophil extracellular trap formation and how blood proteins physiologically restrain it.

Key takeaways
  • Mass spectrometry found seven S100 proteins and ten histone variants released during NET formation.
  • TLR2 antagonism blocked NET formation when applied up to three hours post-stimulation.
  • Human serum albumin captured S100 proteins and prevented NET formation in vitro.
ETH D-HEST News01 Jun 2026
Protection for newborns: new treatment aims to prevent meningitis without antibiotics (ETH D-HEST News)

Protection for newborns: new treatment aims to prevent meningitis without antibiotics

A novel non-antibiotic intestinal therapy aiming to block maternal transmission of dangerous gut bacteria to newborns.

Key takeaways
  • Newborn meningitis is one of the most dangerous childhood infections.
  • It is often life-threatening and can cause serious and lasting damage.
  • Although meningitis is thankfully rare in newborns as a whole.
Science Daily - Health & Medicine31 May 2026
Why cancer spreads more in middle age than in old age (Science Daily - Health & Medicine)

Why cancer spreads more in middle age than in old age

Examine age-related patterns in melanoma spread and the role of specific immune cells that influence tumor dormancy across mouse lifespans.

Key takeaways
  • Melanoma metastasis was lowest in young mice and highest in middle-aged mice.
  • Metastasis incidence declined again in very old mice compared with middle age.
  • Specialized T-cell population that supports tumor dormancy and limits spread.