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Masters of Longevity - The Pulse

Feature31 Aug 2026

Can You Really Measure Whether You’re Aging More Slowly?

A younger epigenetic-age score can look like proof that an intervention is working. A major new analysis shows which clocks detect change—and why movement is not yet the same as longer healthspan.

A blood sample tube centred on a biological-age dial with lifespan rings, biomarker nodes, and molecular patterns.

Editorial Picks

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Growth Hormone Receptor Deletion Extends Mouse Lifespan

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Semaglutide Extended Lifespan in Mice. What Would Make It a Human Longevity Drug?

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The Royal National Academy of Medicine of Spain in Madrid, venue of the International Longevity Summit 2026.

International Longevity Summit Madrid 2026

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Creatine and Cancer: Why New Mouse Studies Point in Opposite Directions

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Trending News

Based on last 48h engagement

  1. 01Growth Hormone Receptor Deletion Extends Mouse Lifespan (Masters of Longevity)Growth Hormone Receptor Deletion Extends Mouse LifespanMasters of Longevity • 10 Sept 2026
  2. 02International Longevity Summit Madrid 2026 (Masters of Longevity)International Longevity Summit Madrid 2026Masters of Longevity • 01 Sept 2026
  3. 03A binding-to-release strategy for targeted anticancer drug delivery - Nature (Nature - Main)A binding-to-release strategy for targeted anticancer drug delivery - NatureNature - Main • 26 Aug 2026
  4. 04Rewiring the ribosome to translate proteins encoded in its own RNA - Nature (Nature - Main)Rewiring the ribosome to translate proteins encoded in its own RNA - NatureNature - Main • 02 Sept 2026
  5. 05Late-life semaglutide treatment slows ageing and extends lifespan in female mice - Nature (Nature - Main)Late-life semaglutide treatment slows ageing and extends lifespan in female mice - NatureNature - Main • 02 Sept 2026

Upcoming Events

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  1. 75th Annual Scientific Meeting of the BSRA: The Biology of Ageing (Oxford, United Kingdom)9. SEPT 2026 - 11. SEPT 202675th Annual Scientific Meeting of the BSRA: The Biology of AgeingConference - Oxford, UK
  2. ReGen Congress 2026 (New Delhi, India)11. SEPT 2026 - 12. SEPT 2026ReGen Congress 2026Conference - New Delhi, India
  3. Biohacking Congress Bad Dürrheim 2026 (Bad Dürrheim, Germany)11. SEPT 2026 - 13. SEPT 2026Biohacking Congress Bad Dürrheim 2026Conference - Bad Dürrheim, Germany
  4. Health Optimisation Summit London (London, United Kingdom)11. SEPT 2026 - 13. SEPT 2026Health Optimisation Summit LondonSummit - London, UK
  5. International Longevity Summit Madrid 2026 (Madrid, Spain)28. SEPT 2026 - 1. OCT 2026International Longevity Summit Madrid 2026Summit - Madrid, Spain★

Latest in Longevity

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Frontiers - Health04 Sept 2026
AIAdjunctive traditional Chinese medicine for ischemic stroke: a systematic review with structured narrative synthesis and GRADE assessment of randomized controll

Adjunctive traditional Chinese medicine for ischemic stroke: a systematic review with structured narrative synthesis and GRADE assessment of randomized controlled trials

A structured systematic review evaluates randomized trials of specific traditional Chinese medicine formulations used alongside standard care for ischemic stroke across acute, recovery, and prevention stages.

Key takeaways
  • We searched seven bibliographic databases and one clinical trial registry to 8 April 2026.
  • Nine RCTs enrolling 12,348 randomized participants were eligible.
  • Ischemic stroke is a leading cause of death and long-term disability.
Fight Aging!03 Sept 2026
AISenescent Microglia Secrete DLK1, Which Causes Dysfunction in the Aging Brain (Fight Aging!)

Senescent Microglia Secrete DLK1, Which Causes Dysfunction in the Aging Brain

Examines how senescent microglia secrete a soluble Notch ligand that impairs oligodendrocytes and neuronal function in aging brains.

Key takeaways
  • Senescent microglia with shortened telomeres secrete increased soluble DLK1 into cerebrospinal fluid.
  • Elevated sDLK1 in vivo caused hypomyelination and blocked oligodendrocyte lineage progression.
  • SDLK1 impaired oligodendrocyte maturation and altered calcium signaling in human iPSC-derived neurons.
Frontiers - Health04 Sept 2026
AIThirty-Five Years of Evolving Inflammatory Paradigms in Sepsis (1991–2025): A Comprehensive Mapping of Immune Dysregulation Research, Anti-Inflammatory Targets,

Thirty-Five Years of Evolving Inflammatory Paradigms in Sepsis (1991–2025): A Comprehensive Mapping of Immune Dysregulation Research, Anti-Inflammatory Targets, and Translational Barriers

A temporal, computational review maps 1991–2025 sepsis inflammatory research shifts, trending from broad cytokine focus to targeted immune mechanism exploration.

Key takeaways
  • You have multiple emails registered with Frontiers: You don't have a Frontiers account ?.
  • Were retrieved from PubMed and the Web of Science Core Collection.
  • Co-cited references were graded by Oxford Centre for Evidence-Based Medicine (OCEBM).
MoL Event Pick
Longevity Wellness Expo 2026 (Toronto, Canada)

Longevity Wellness Expo 2026

2. OCT 2026 - 4. OCT 2026 - Toronto, CanadaExpo

Toronto expo and conference focused on longevity, wellness, biohacking, health optimization and healthy aging products and services.

Register
Longevity Technology03 Sept 2026
AIMinicircle named XPRIZE Healthspan finalist (Longevity Technology)

Minicircle named XPRIZE Healthspan finalist

Minicircle’s XPRIZE Healthspan finalist status — a brief look at a gene‑therapy developer advancing to late-stage competition with plans for human trials.

Key takeaways
  • Minicircle advanced to the final 10 in the XPRIZE Healthspan competition for measurable rejuvenation trials.
  • Company received a $1 million finalist cash prize to support a placebo-controlled human clinical trial.
  • Minicircle’s trial will study a scalable combination gene therapy targeting adults aged fifty to eighty.