Masters of Longevity - The Pulse

Frontiers - Health25 Jul 2026
AITrastuzumab-Deruxtecan as 11th line therapy in a metastasized ovarian clear cell carcinoma patient expressing HER2 1+ (Frontiers - Health)

Trastuzumab-Deruxtecan as 11th line therapy in a metastasized ovarian clear cell carcinoma patient expressing HER2 1+

Report of a heavily pretreated ovarian clear cell carcinoma patient who showed a meaningful response to HER2-directed antibody drug conjugate despite low HER2 expression.

Key takeaways
  • You have multiple emails registered with Frontiers: You don't have a Frontiers account ?
  • You can register here Ovarian clear cell carcinoma (OCCC).
  • Formatted version of the article will be published soon.
Youtube — Bryan Johnson24 Jul 2026
All of my sauna knowledge (Youtube — Bryan Johnson)

All of my sauna knowledge

Practical, experience-driven guidance on using dry saunas for longevity, covering frequency, timing, safety, and acclimation tips.

Key takeaways
  • 11 minutes at 176° is when benefits start.
  • Wet and infrared saunas lack evidence for longevity benefits.
  • Expect your sleep and HRV to be wrecked in the first two weeks.
Fight Aging!24 Jul 2026
AISmall Molecule GPR40 Agonism Restores Thymic Activity in Aged Mice (Fight Aging!)

Small Molecule GPR40 Agonism Restores Thymic Activity in Aged Mice

This article previews a mouse-study news piece about a small-molecule approach to revive age‑worn thymus function, highlighting experimental context and implications.

Key takeaways
  • GPR40 agonist given by injection reportedly increased thymic activity in aged mice over a few weeks.
  • Study groups were small, with some experiments using as few as three to five mice per group.
  • Authors propose reduced inflammation and altered thymic epithelial cell signaling as possible mechanisms.
Longevity Technology24 Jul 2026
Brain scans hint at new way to slow Alzheimer’s (Longevity Technology)

Brain scans hint at new way to slow Alzheimer’s

Brain-imaging feature story about research using network-based scans to assess a synapse-targeting oral therapy and its implications for personalized Alzheimer’s care.

Key takeaways
  • Latest generation of FDA-approved drugs aims to clear these sticky protein deposits from the brain.
  • Race against Alzheimer’s disease has largely revolved around amyloid plaques.
  • New findings presented at the Alzheimer’s Association International Conference (AAIC).