Masters of Longevity - The Pulse

Nature - Main01 Jun 2026
How long can humans live? We simply don’t know (Nature - Main)

How long can humans live? We simply don’t know

Examine critiques of extreme-longevity claims and the data-quality problems that undermine estimates of human maximum lifespan.

Key takeaways
  • Newman found a 72% rate of pension-fraud-related centenarian records in Greece.
  • Biomarkers calibrated to paperwork cannot distinguish biological age from record errors.
  • Saul Newman argues many extreme longevity records are explained by faulty documentation.
Frontiers - Health01 Jun 2026
AIEditorial: Deciphering the microbiome (Frontiers - Health)

Editorial: Deciphering the microbiome

An editorial synthesizing recent research on gut–lung microbiome dysbiosis and its proposed links to interstitial lung diseases, diagnostics, and therapeutic strategies.

Key takeaways
  • Idiopathic pulmonary fibrosis shows reduced lung microbiome diversity and higher bacterial burden.
  • Metagenomic sequencing can detect antibiotic resistance genes and guide antibiotic stewardship.
  • Fungal genera including Candida, Saccharomyces, and Penicillum are implicated in sarcoidosis.
Nature - Main01 Jun 2026
Obesity doesn’t equate to ill health: why the ‘disease’ label doesn’t always fit (Nature - Main)

Obesity doesn’t equate to ill health: why the ‘disease’ label doesn’t always fit

Obesity receives a thoughtful, evidence-informed commentary exploring nuanced perspectives on stigma and how medical framing shapes care and policy.

Key takeaways
  • 56-expert international commission convened by The Lancet proposed clinical and preclinical obesity.
  • Seventy-six medical organizations worldwide endorsed the commission's proposed classification.
  • Some specialist societies argue the distinction could complicate diagnosis and restrict treatments.
Frontiers - Health01 Jun 2026
AIA feedback loop sustaining neutrophil extracellular trap formation involves S100 proteins, histones, TLR2 and RAGE, and is restrained by albumin (Frontiers - He

A feedback loop sustaining neutrophil extracellular trap formation involves S100 proteins, histones, TLR2 and RAGE, and is restrained by albumin

Learn about a newly described immune feedback loop that sustains neutrophil extracellular trap formation and how blood proteins physiologically restrain it.

Key takeaways
  • Mass spectrometry found seven S100 proteins and ten histone variants released during NET formation.
  • TLR2 antagonism blocked NET formation when applied up to three hours post-stimulation.
  • Human serum albumin captured S100 proteins and prevented NET formation in vitro.