Describes a woven decellularized extracellular matrix yarn scaffold that restructures scaffold architecture to promote volumetric muscle loss regeneration via immune and tissue remodeling.
Key Takeaways
- 3D woven dECM yarn scaffold enabled full interconnectivity and high porosity for implanted scaffolds
- In murine VML models the scaffold improved vascularization, innervation, muscle mass, and strength restoration
- Single-nucleus RNA-seq showed reduced SPP1+ neutrophils and increased CD206+/IGF-1+ macrophages driving IGF-1R signaling