Review of how diverse peritoneal macrophage populations drive immune suppression and therapeutic resistance during gastric cancer peritoneal metastasis.
Key Takeaways
- Peritoneal metastasis is the most devastating form of progression of gastric cancer
- Reprogrammed macrophages proceed to participate in detachment of tumor cells
- Important molecular players that we describe here are CCL2/CCR2 and CSF-1/CSF-1R signaling axes