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Spatial immune ecosystems and therapy resistance in large B-cell lymphoma: from single-cell multi-omics to immunotherapy-matched validation

Source: Frontiers - Health • Published: 25 Aug 2026, 00:00

Spatial immune ecosystems and therapy resistance in large B-cell lymphoma: from single-cell multi-omics to immunotherapy-matched validation

Review of how single-cell and spatial multi-omics map tumor and immune architectures in large B-cell lymphoma and guide pathology-ready biomarker development.

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  • Although molecular classification has refined the understanding of lymphoma biology
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