Longevity News

TLR9-engineered photoresponsive biomimetic nanodecoys for targeted NETs clearance to mitigate periodontitis-associated bone resorption

Source: Nature - Biotechnology • Published: 25 Aug 2026, 00:00

TLR9-engineered photoresponsive biomimetic nanodecoys for targeted NETs clearance to mitigate periodontitis-associated bone resorption

Describes a biomimetic, photoresponsive nanodecoy that uses TLR9-recognizing membranes and DNase I to target and clear NETs and support periodontal bone repair.

Key Takeaways
  • Periodontitis is a widespread and multifactorial inflammatory disease
  • Treatment of periodontitis is complicated by complex interactions between the host and oral microbiota
  • Periodontitis is a chronic inflammatory disease driven by host‒microbial interactions
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