Review and original studies synthesize multi-omics maps of tumor-associated macrophage diversity and therapeutic targets across multiple solid cancers.
Key Takeaways
- Within this milieu, tumor-associated macrophages (TAMs) have emerged as central orchestrators of immunosuppression
- While traditionally oversimplified into a dichotomy of anti-tumoral (M1)
- Present a multi-omics perspective on TAM plasticity during androgen deprivation therapy and PARP inhibition