Examines whether CXCR6-positive natural killer cells provide enhanced antiviral activity and preserve CD4+ T cells after HIV exposure in humanized mice.
Key Takeaways
- Because HIV-responsive adaptive NK-cell activity is enriched among CXC chemokine receptor 6-positive (CXCR6 + )
- In co-cultures with HIV-infected primary CD4 + T cells
- HIV-Env vaccination further enriched NK cells with enhanced therapeutic activity