Single-cell epigenetics: a short piece introducing a study-style explainer that shows how epigenetic profiling uncovers cell identities overlooked by RNA-only approaches and why combined single-cell multiomic work matters.
Key Takeaways
- Single-cell epigenetic profiling revealed microglia identities missed by single-cell RNA sequencing
- Findings indicate many aged brain samples contained embryonically derived microglia not previously recognized
- Speakers call for continued single-cell genetics and epigenetics work to expand understanding of brain aging