A nanopore single-molecule platform was used to monitor the full phenylalanine-to-adrenaline biosynthetic pathway in real time, detecting key intermediates and perturbations.
Key Takeaways
- Although they are synthesized through a branched phenylalanine metabolic pathway
- We show that 6-methylisothiocyanate disrupts catecholamine biosynthesis
- These data are available via Zenodo at https