Reports preclinical evidence that a colon-targeted indole-3-acetic acid starch derivative preserves immune organ integrity and gut barrier function in chemotherapy-treated mice.
Key Takeaways
- HAMSIAA restored splenic CD4+/CD8+ T cell balance and increased serum IgA, IgG, and IgM levels
- HAMSIAA improved intestinal barrier markers and shifted gut microbiota, lowering Pseudomonadota abundance
- Untargeted metabolomics linked HAMSIAA to purine salvage pathway changes, including altered inosine and xanthine levels