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Granule cells reorient cortical trajectories to separate contexts - Nature

Source: Nature - Main • Published: 26 Aug 2026, 00:00

Granule cells reorient cortical trajectories to separate contexts - Nature

Cerebellar–cortical circuit dynamics during dual-skill learning, showing how one brain region preserves generalizable activity while another reconfigures trajectories to separate contexts.

Key Takeaways
  • Premotor L5 pyramidal tract activity generalized across both learned tasks
  • Cerebellar granule cell population trajectories rotated apart to separate task contexts
  • Trajectory divergence in granule cells was strongest in expert mice
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