Reports discovery of inflammation-induced chimeric mRNAs in macrophages and one protein-coding fusion that modulates inflammasome-driven pore formation.
Key Takeaways
- Individual mammalian mRNAs and proteins are typically believed to originate from single genomic loci
- We show that inflammasome priming upregulates Gsdmd - Tmem106a , with the protein localizing to the plasma membrane
- We show that GSDMD–TMEM106A balances host defence and immunopathology in vivo