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Engineering inflammation-responsive proteins through nitric oxide-caged amino acids

Source: Nature - Biotechnology • Published: 31 Aug 2026, 00:00

Engineering inflammation-responsive proteins through nitric oxide-caged amino acids

Describes a protein engineering method that uses nitric oxide-triggered decaging of masked amino acids to restore protein function selectively in inflamed tissues.

Key Takeaways
  • 2: Characterization of NO-responsive activation in engineered antibody and luciferase
  • 5: NO-responsive AAV enables gene transduction specifically in inflamed liver
  • Any additional raw data and materials are available from the corresponding author (T.L.) on reasonable request
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