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Advances in Rapid ADAMTS13 Testing for Thrombotic Thrombocytopenic Purpura: A Systematic Review of Diagnostic Assays and the Role of Clinical Probability Tools

Source: Frontiers - Health • Published: 30 Aug 2026, 00:00

Advances in Rapid ADAMTS13 Testing for Thrombotic Thrombocytopenic Purpura: A Systematic Review of Diagnostic Assays and the Role of Clinical Probability Tools

Rapid-testing and clinical-score advances for diagnosing acute TTP are described, previewing a review of assays, prediction tools, and diagnostic pathways.

Key Takeaways
  • HemosIL AcuStar showed 100% sensitivity and 94.6–98.9% specificity with a 33-minute turnaround time
  • CLEIA provided near-perfect agreement with reference methods and returned results in about 17 minutes
  • Bedside Technoscreen delivered 100% sensitivity and 90% specificity with results available in roughly 10 minutes
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