Cognitive trajectories in myotonic dystrophy type 1 are examined through longitudinal studies, guiding readers to patterns of change across age-related phenotypes.
Key Takeaways
- Sixteen longitudinal studies were identified with follow-ups from one to twenty years
- Pediatric DM1 showed baseline intellectual disability with largely stable cognitive trajectories
- Adult and late-onset DM1 exhibited slow progressive decline, especially in visuoconstruction and processing speed