Aberrant excitatory-neuron ERBB4 expression is the focus of a research article exploring a newly identified neuronal subtype's role in early Alzheimer’s disease mechanisms.
Key Takeaways
- Single-nucleus RNA-seq identified early-responsive excitatory neurons expressing ectopic Erbb4 in AD mouse models
- Deleting Erbb4 in excitatory neurons prevented synapse loss
- Erbb4-driven effects required mTOR signalling and overexpression induced AD-like phenotypes without amyloid plaques