Single-cell genomics research showing how cell-type-specific genetic effects on expression shape the biology behind complex traits, inviting readers to learn the study’s approach and implications.
Key Takeaways
- Cell-type-specific eQTLs are enriched for complex trait heritability compared with shared eQTLs
- Transcriptome-wide, 60% of trans eQTLs were cell-type-specific while only 30% of cis eQTLs were specific
- Findings replicated in an independent single-cell dataset and were consistent across ancestries