Examines evidence that reduced glymphatic cerebrospinal fluid drainage, measured by DTI-ALPS MRI, tracks with Alzheimer's disease progression and cognitive decline.
Key Takeaways
- Meta-analysis of 22 studies found significant correlation between DTI-ALPS index and amyloid-β PET deposition
- DTI-ALPS index significantly correlated with MMSE and MoCA cognitive scores across pooled studies
- DTI-ALPS values were lower in Alzheimer’s disease and mild cognitive impairment groups versus controls