Masters of Longevity - The Pulse

Nature - Biotechnology23 Jul 2026
Combinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses (Nature - Biotechnology)

Combinatorial in situ cancer vaccines: unlocking broad and enhanced antitumor responses

Discusses combinatorial in situ cancer vaccination approaches that transform tumors into antigen sources and combine adjuvants and delivery technologies to boost systemic antitumor immunity.

Key takeaways
  • Therapeutic efficacy of this approach arises from the coordinated activation of multiple immune mechanisms.
  • These innovations position in situ cancer vaccination as a patient-tailored.
  • Recent clinical investigations have underscored the therapeutic potential of in situ vaccination.
Frontiers - Health23 Jul 2026
AIPsoriasis as a Spatial Immune Ecosystem: Insights from Single Cell and Spatial Transcriptomics (Frontiers - Health)

Psoriasis as a Spatial Immune Ecosystem: Insights from Single Cell and Spatial Transcriptomics

A review synthesizing single-cell and spatial transcriptomics studies that reconceptualize psoriasis as a dynamic, spatially organized immune and stromal ecosystem.

Key takeaways
  • You have multiple emails registered with Frontiers: You don't have a Frontiers account ?
  • Keratinocytes and fibroblasts have moved beyond their traditionally passive roles as target cells.
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
MoL Event Pick
MedTech World Asia | Hong Kong 2026 (Hong Kong, Hong Kong)

MedTech World Asia | Hong Kong 2026

26. AUG 2026 - 28. AUG 2026 - Hong Kong, Hong KongSummit

Hong Kong summit connecting MedTech and HealthTech leaders, startups, investors, hospital executives, regulators and innovators across APAC healthcare innovation.

Nature - Biotechnology23 Jul 2026
AICellGeometry: ultra-fast single-cell deconvolution of bulk RNA-Seq using a geometric solution (Nature - Biotechnology)

CellGeometry: ultra-fast single-cell deconvolution of bulk RNA-Seq using a geometric solution

CellGeometry introduces a fast, geometry-based computational approach for deconvoluting bulk RNA-Seq using single-cell reference signatures; readers will find a methods-focused article explaining its design and benchmarking.

Key takeaways
  • Validated against real bulk RNA blood and tissue samples, cellGeometry produces more accurate and realistic results.
  • Please note there may be errors present which affect the content, and all legal disclaimers apply.
  • Single-cell analysis has rapidly expanded to produce cell atlases encompassing all human tissues.
Frontiers - Health23 Jul 2026
AITumor progression is effectively suppressed by miR-195 through direct targeting of YAP1 (Frontiers - Health)

Tumor progression is effectively suppressed by miR-195 through direct targeting of YAP1

Summarizes a study identifying microRNA regulation of Hippo pathway effector YAP1 and its impact on tumor cell growth in models.

Key takeaways
  • MiR-195 directly binds the YAP1 3' UTR and abolishes reporter activity when the seed site is intact.
  • MiR-195 overexpression reduces endogenous YAP1 protein and lowers CTGF expression in cultured cells.
  • Stable miR-195 overexpression suppressed xenograft tumor growth and low miR-195 correlates with poorer patient survival.