Feature
MOTS-c: Where the Evidence Ends
Studies offer clues about ageing and metabolism. What do they actually tell us about human health—and where does expert opinion take over?
Fight Aging!
The APOEε4 Variant Interferes in Myelination in the Aging Brain
APOE4 reduced Wnt–beta‑catenin signaling in oligodendrocytes, causing lipid droplets and impaired myelination in cell and mouse models.
Key takeaways
- APOE4 oligodendrocytes showed reduced beta‑catenin and higher GSK3b levels.
- GSK3b inhibition restored Wnt signaling and increased myelination in models.
- Lipid droplets accumulated in oligodendrocytes when Wnt signaling was depressed.
