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Masters of Longevity - The Pulse

Feature20 Oct 2026

MOTS-c: Where the Evidence Ends

Studies offer clues about ageing and metabolism. What do they actually tell us about human health—and where does expert opinion take over?

MOTS-c: Where the Evidence Ends

By The Peptide Dosing editorial team

Studies offer clues about ageing and metabolism. What do they actually tell us about human health—and where does expert opinion take over?

Feature20 Oct 2026
Abstract illustration of mitochondria with folded inner membranes in a cell

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  1. 01Gradient-driven microfluidic framework for the screening of ratiometric drug combinations towards precision oncology in paediatric leukaemia (Nature - Biotechn...Gradient-driven microfluidic framework for the screening of ratiometric drug combinations towards precision oncology in paediatric leukaemiaNature - Biotechnology • 23 Oct 2026External link, opens in a new tab
  2. 02The Results of Phase III OptiTROP-Lung06 Study of Sacituzumab Tirumotecan (sac-TMT) Presented as an ESMO Oral Presentation and Simultaneous... (PR Newswire)The Results of Phase III OptiTROP-Lung06 Study of Sacituzumab Tirumotecan (sac-TMT) Presented as an ESMO Oral Presentation and Simultaneously Published in The New England Journal of MedicinePR Newswire • 25 Oct 2026External link, opens in a new tab
  3. 03Fight Aging! Newsletter, October 26th 2026 (Fight Aging!)Fight Aging! Newsletter, October 26th 2026Fight Aging! • 25 Oct 2026External link, opens in a new tab
  4. 04Final OS Analysis Results from Phase III OptiTROP-Lung04 Study of Sacituzumab Tirumotecan (sac-TMT) Presented at 2026 ESMO (PR Newswire)Final OS Analysis Results from Phase III OptiTROP-Lung04 Study of Sacituzumab Tirumotecan (sac-TMT) Presented at 2026 ESMOPR Newswire • 25 Oct 2026External link, opens in a new tab
  5. 05Holographic focused ultrasound enables multitarget EV and MSC delivery for neurovascular repair after ischemic stroke (Nature - Biotechnology)Holographic focused ultrasound enables multitarget EV and MSC delivery for neurovascular repair after ischemic strokeNature - Biotechnology • 25 Oct 2026External link, opens in a new tab

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Latest in Longevity

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NewLimit21 Oct 2026
2026 Summer (NewLimit)

2026 Summer

NewLimit reported expanded RNA manufacturing and preparations for nonclinical safety testing, ahead of potential human trials.

Key takeaways
  • The company reports expanding LNP-RNA manufacturing by over 314-fold.
  • Safety testing is planned before any potential human trials.
  • Therapeutic safety and efficacy remain unproven by manufacturing progress.
Neuroscience News21 Oct 2026
Restoring Brain Growth in Angelman Syndrome (Neuroscience News)

Restoring Brain Growth in Angelman Syndrome

Researchers identified a stress pathway in Angelman models that impaired protein production; inhibiting ASNS helped mice.

Key takeaways
  • Loss of maternal UBE3A caused ASNS to accumulate in neurons.
  • ASNS accumulation triggered stress that impaired protein production.
  • Blocking ASNS restored brain growth and behaviour in mice.
Youtube — Siim Land21 Oct 2026
How I Reached Top 1% Metabolic Health With These Changes (Youtube — Siim Land)

How I Reached Top 1% Metabolic Health With These Changes

Siim Land says his A1c, fasting glucose, triglycerides and visceral fat fell after dietary shifts.

Key takeaways
  • Siim Land says higher carbohydrate intake was associated with lower A1c.
  • Siim Land says his self-tracked metabolic changes are from one individual.
  • The speaker’s observations are not proof of causation in others.
Fitt Insider - Press Releases21 Oct 2026
AISupernatural Launches Metabolic Optimization Membership—Putting Personalized Care and Longevity at the Forefront of the GLP-1 Revolution (Fitt Insider - Press R

Supernatural Launches Metabolic Optimization Membership—Putting Personalized Care and Longevity at the Forefront of the GLP-1 Revolution

Supernatural launched a paid membership combining individualized metabolic testing, medical oversight, and coaching.

Key takeaways
  • The membership combines metabolic testing, medical oversight and coaching.
  • The programme is intended to support weight and metabolic health.
  • Clinical benefit from this programme has not yet been established.