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Masters of Longevity - The Pulse

Feature31 Aug 2026

Can You Really Measure Whether You’re Aging More Slowly?

A younger epigenetic-age score can look like proof that an intervention is working. A major new analysis shows which clocks detect change—and why movement is not yet the same as longer healthspan.

A blood sample tube centred on a biological-age dial with lifespan rings, biomarker nodes, and molecular patterns.

Editorial Picks

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Growth Hormone Receptor Deletion Extends Mouse Lifespan

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Semaglutide Extended Lifespan in Mice. What Would Make It a Human Longevity Drug?

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The Royal National Academy of Medicine of Spain in Madrid, venue of the International Longevity Summit 2026.

International Longevity Summit Madrid 2026

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Creatine and Cancer: Why New Mouse Studies Point in Opposite Directions

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Biotin for Hair Growth: The Weak Evidence—and the Blood-Test Risk Most People Miss

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Trending News

Based on last 48h engagement

  1. 01Growth Hormone Receptor Deletion Extends Mouse Lifespan (Masters of Longevity)Growth Hormone Receptor Deletion Extends Mouse LifespanMasters of Longevity • 10 Sept 2026
  2. 02International Longevity Summit Madrid 2026 (Masters of Longevity)International Longevity Summit Madrid 2026Masters of Longevity • 01 Sept 2026
  3. 03A binding-to-release strategy for targeted anticancer drug delivery - Nature (Nature - Main)A binding-to-release strategy for targeted anticancer drug delivery - NatureNature - Main • 26 Aug 2026
  4. 04Rewiring the ribosome to translate proteins encoded in its own RNA - Nature (Nature - Main)Rewiring the ribosome to translate proteins encoded in its own RNA - NatureNature - Main • 02 Sept 2026
  5. 05Creatine and Cancer: Why New Mouse Studies Point in Opposite Directions (Masters of Longevity)Creatine and Cancer: Why New Mouse Studies Point in Opposite DirectionsMasters of Longevity • 27 Aug 2026

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  1. 75th Annual Scientific Meeting of the BSRA: The Biology of Ageing (Oxford, United Kingdom)9. SEPT 2026 - 11. SEPT 202675th Annual Scientific Meeting of the BSRA: The Biology of AgeingConference - Oxford, UK
  2. ReGen Congress 2026 (New Delhi, India)11. SEPT 2026 - 12. SEPT 2026ReGen Congress 2026Conference - New Delhi, India
  3. Biohacking Congress Bad Dürrheim 2026 (Bad Dürrheim, Germany)11. SEPT 2026 - 13. SEPT 2026Biohacking Congress Bad Dürrheim 2026Conference - Bad Dürrheim, Germany
  4. Health Optimisation Summit London (London, United Kingdom)11. SEPT 2026 - 13. SEPT 2026Health Optimisation Summit LondonSummit - London, UK
  5. International Longevity Summit Madrid 2026 (Madrid, Spain)28. SEPT 2026 - 1. OCT 2026International Longevity Summit Madrid 2026Summit - Madrid, Spain★

Latest in Longevity

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Swiss Biotech02 Sept 2026
AINewBiologix and Synastra partner on gene therapy manufacturing (Swiss Biotech)

NewBiologix and Synastra partner on gene therapy manufacturing

A biotech partnership story about developing stable producer cell lines for scalable gene therapy manufacturing; a forward-looking take on enabling DMD program development.

Key takeaways
  • Addressing a Critical Manufacturing Challenge in DMD Gene Therapy Duchenne muscular dystrophy is a severe.
  • It is caused by mutations in the DMD gene that prevent the production of functional dystrophin.
  • Manufacturing is particularly critical for DMD gene therapies.
Nature - Main02 Sept 2026
Late-life semaglutide treatment slows ageing and extends lifespan in female mice - Nature (Nature - Main)

Late-life semaglutide treatment slows ageing and extends lifespan in female mice - Nature

Late-life semaglutide treatment in mice: a research article examining whether a diabetes drug can mimic calorie restriction to slow ageing and preserve function. Open to learn what kind of experimental and comparative study the paper presents and why it matters for ageing research.

Key takeaways
  • Use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control 2.
  • In a longitudinal study in direct comparison to matched calorie restriction.
  • Attenuated hallmarks of ageing and modulated nutrient sensors and conserved genetic regulators of ageing.
Frontiers - Health02 Sept 2026
AITumor-associated macrophages in gastric cancer peritoneal metastasis: orchestrating immune evasion, niche remodeling, and therapeutic resistance (Frontiers - He

Tumor-associated macrophages in gastric cancer peritoneal metastasis: orchestrating immune evasion, niche remodeling, and therapeutic resistance

Review of how diverse peritoneal macrophage populations drive immune suppression and therapeutic resistance during gastric cancer peritoneal metastasis.

Key takeaways
  • Important molecular players that we describe here are CCL2/CCR2 and CSF-1/CSF-1R signaling axes.
  • Peritoneal metastasis is the most devastating form of progression of gastric cancer.
  • Reprogrammed macrophages proceed to participate in detachment of tumor cells.
MoL Event Pick
International Longevity Summit Madrid 2026 (Madrid, Spain)

International Longevity Summit Madrid 2026

28. SEPT 2026 - 1. OCT 2026 - Madrid, SpainSummit

Madrid summit convening global longevity thinkers, clinicians and innovators across four days of science, networking and public-facing programming.

Register
Nature - Main02 Sept 2026
Functional chimeric mRNAs encode proteins in mammalian immunity - Nature (Nature - Main)

Functional chimeric mRNAs encode proteins in mammalian immunity - Nature

Reports discovery of inflammation-induced chimeric mRNAs in macrophages and one protein-coding fusion that modulates inflammasome-driven pore formation.

Key takeaways
  • We show that inflammasome priming upregulates Gsdmd - Tmem106a.
  • We show that GSDMD–TMEM106A balances host defence and immunopathology in vivo.
  • Individual mammalian mRNAs and proteins are typically believed to originate from single genomic loci.