Masters of Longevity - The Pulse

Frontiers - Health03 Sept 2026
AIHAMSIAA protects cyclophosphamide induced immunosuppression by modulating gut homeostasis and purine metabolism (Frontiers - Health)

HAMSIAA protects cyclophosphamide induced immunosuppression by modulating gut homeostasis and purine metabolism

Reports preclinical evidence that a colon-targeted indole-3-acetic acid starch derivative preserves immune organ integrity and gut barrier function in chemotherapy-treated mice.

Key takeaways
  • HAMSIAA restored splenic CD4+/CD8+ T cell balance and increased serum IgA, IgG, and IgM levels.
  • HAMSIAA improved intestinal barrier markers and shifted gut microbiota, lowering Pseudomonadota abundance.
  • Untargeted metabolomics linked HAMSIAA to purine salvage pathway changes.
Longevity Technology02 Sept 2026
AI hunts new uses for Phase 3 metabolic drug (Longevity Technology)

AI hunts new uses for Phase 3 metabolic drug

An AI-driven reverse‑engineering approach mines existing pharmacology and gene expression data to reveal additional disease targets for a late‑stage metabolic drug.

Key takeaways
  • THPharm already has a drug in late-stage trials.
  • THPharm , a South Korean biotech focused on metabolic disease, is trying it the other way around.
  • Start with a drug that already works; let an AI system figure out everything else it might treat.
Frontiers - Health03 Sept 2026
AIPredictive modeling of axillary web syndrome in Chinese postoperative breast cancer patients using interpretable machine learning (Frontiers - Health)

Predictive modeling of axillary web syndrome in Chinese postoperative breast cancer patients using interpretable machine learning

A paper develops and validates interpretable machine learning models to predict axillary web syndrome risk after breast cancer surgery, comparing algorithms and clinical predictors.

Key takeaways
  • Patients aged 60 and older had a 73% higher AWS risk compared with younger patients.
  • AWS occurrence within one month post-surgery raised threefold the risk of lymphedema within three months.
  • Postoperative lymphedema was identified as a significant risk factor for axillary web syndrome.
Fight Aging!02 Sept 2026
AIAn Adiponectin Receptor Agonist Promotes Muscle Growth in Rats (Fight Aging!)

An Adiponectin Receptor Agonist Promotes Muscle Growth in Rats

A short primer on a preclinical research article testing a small‑molecule adiponectin receptor agonist as a potential way to stimulate muscle growth and function in rodent models, useful for readers curious about emerging pharmacological strategies against muscle atrophy.

Key takeaways
  • Therapies that inhibit myostatin or upregulate follistatin signaling are under development.
  • But most of the research community is focused on pharmacology.
  • Skeletal muscle atrophy is a hallmark of ageing and chronic diseases.