Masters of Longevity - The Pulse

Nature - Biotechnology19 Jun 2026
Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models (Nature - Biotechnology)

Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models

Assessment of a liver-targeted integrating vector restoring cellular architecture and evaluating safety in preclinical models of infantile liver disease.

Key takeaways
  • Although causality remains unproven and no additional neoplasms have been reported 6.
  • They have also showed favourable safety profiles in early-phase in vivo clinical trials.
  • Our group has shown liver phenotype rescue using adeno-associated vector (AAV).
Frontiers - Health19 Jun 2026
AIThe Immune System as a Regulator of Normal Physiology (Frontiers - Health)

The Immune System as a Regulator of Normal Physiology

Examine evolving models that reframe the immune system as a regulator of tolerance, tissue repair, metabolic balance, and homeostasis.

Key takeaways
  • Lions Eye Institute, University of Aberdeen, Aberdeen, United Kingdom, WA, 6014 2.
  • Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom, WA, 6014 3.
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Nature - Biotechnology19 Jun 2026
AIA combinatorial therapeutic platform based on graphene–collagen cryogel and apoptotic vesicles for modulating hypertrophic scars (Nature - Biotechnology)

A combinatorial therapeutic platform based on graphene–collagen cryogel and apoptotic vesicles for modulating hypertrophic scars

A combinatorial biomaterial and vesicle therapy is evaluated for modulating fibroblast-driven hypertrophic scarring and local delivery.

Key takeaways
  • Graphene–collagen cryogel reduced COL1A1, α-SMA, and Vimentin expression in HS fibroblasts.
  • Combined cryogel plus vesicle treatment lowered scar elevation index and increased M2 macrophages.
  • Adipose stem cell apoptotic vesicles decreased collagen and α-SMA expression in vitro.
Frontiers - Health19 Jun 2026
AISingle-Point Insulin Sensitivity Estimator and Left Main and/or Three-Vessel Disease in Patients Aged 45 Years or Older with Acute Coronary Syndrome: Findings f

Single-Point Insulin Sensitivity Estimator and Left Main and/or Three-Vessel Disease in Patients Aged 45 Years or Older with Acute Coronary Syndrome: Findings from the CCC-ACS Project

Assess the link between an easily measured insulin sensitivity marker and severe coronary artery patterns in older acute coronary syndrome patients.

Key takeaways
  • This study examined the association of the single-point insulin sensitivity estimator (SPISE).
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  • Methods: This cross-sectional analysis was based on data from the CCC-ACS project.