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Synergistic effect of insulin resistance and glycemic variability on mortality in ICU patients with gastrointestinal bleeding: impact of the TyG-GVI index and development of an explainable web-based clinical calculator

Source: Frontiers - Health • Published: 04 Sept 2026, 00:00

Synergistic effect of insulin resistance and glycemic variability on mortality in ICU patients with gastrointestinal bleeding: impact of the TyG-GVI index and development of an explainable web-based clinical calculator

This study evaluates a combined triglyceride-glucose and glycemic variability index as a prognostic tool for early mortality among ICU patients with gastrointestinal bleeding.

Key Takeaways
  • Such static metrics may fail to capture temporal changes in metabolic instability
  • Study data were extracted from the MIMIC-IV (release 3.1)
  • This archive spans 94,458 ICU-stay episodes recorded between 2008 and 2022
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