Summarized by Masters of Longevity from Nature - Main.
Mitochondrial fission factor-focused research that explains how organelle dynamics link to ferroptosis and showcases a live-cell biosensor for probing this pathway.
Key Takeaways
- Phosphorylation of mitochondrial fission factor (MFF) at Ser155 is induced by 17-HETE and specifically promotes ferroptosis through organelle remodeling.
- MFF S155 phosphorylation drives coordinated mitochondrial and peroxisomal fragmentation, increasing interorganelle crosstalk and oxidative stress to accelerate ferroptotic death.
- A live-cell MFF-SPARK biosensor revealed PKCβ and DUSP22 as a kinase–phosphatase pair regulating MFF phosphorylation, enabling pharmacological screening such as avermectin B1 activation.
