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Microdroplet-based high-throughput screening for antagonistic bacteria targeting penaeid shrimp pathogenic Vibrio harveyi

Source: Nature - Biotechnology • Published: 02 Sept 2026, 00:00

Microdroplet-based high-throughput screening for antagonistic bacteria targeting penaeid shrimp pathogenic Vibrio harveyi

Describes a microdroplet microfluidics workflow to screen environmental bacteria for antagonism against a shrimp pathogen, isolating rare candidate strains from rearing water.

Key Takeaways
  • Microdroplet-based high-throughput screening platform was developed to test antagonists against Vibrio harveyi
  • Eighteen candidate inhibitory bacterial isolates were recovered, clustering into four OTUs across three genera
  • One of four tested isolates showed a trend toward improved shrimp survival in co-infection experiments
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