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Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis

Source: Frontiers - Health • Published: 21 Aug 2026, 00:00

Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis

Profiles a dual ex vivo and clinical study testing an oral combination of an antioxidant, collagen peptides, and hyaluronate for improving facial skin aging signs and biomarkers.

Key Takeaways
  • Triple combination reversed UV-induced epidermal thinning and collagen fiber disruption ex vivo
  • Treatment up-regulated Nrf2 and SOD2 while lowering IL-1α, IL-6, and MMP1 expression ex vivo
  • Oral administration improved skin hydration, elasticity, barrier function, and reduced wrinkle metrics in Chinese women
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