Reports how a neuropeptide-driven signaling axis links sensory nerves to mast cell activation and inflammation in chronic facial skin disease.
Key Takeaways
- Patients with the skin disease had elevated serum CGRP that correlated with flushing and erythema severity
- Lesional mast cells showed increased CALCRL, RAMP1, phosphorylated JAK3, and phosphorylated STAT1 protein localization
- CGRP stimulated mast-cell degranulation and inflammatory mediator release that was reduced by rimegepant or ritlecitinib