Masters of Longevity - The Pulse

Nature - Main22 Jul 2026
Subnuclear genome compartmentalization controls bivalent chromatin activity - Nature (Nature - Main)

Subnuclear genome compartmentalization controls bivalent chromatin activity - Nature

Reports mapping how three-dimensional subnuclear compartments reorganize during human cortical neurogenesis and regulate bivalent chromatin states and transcriptional activation.

Key takeaways
  • Functional experiments demonstrated that the lamina represses transcription independently of local H3K27me3.
  • Poised state of bivalent genes embedded in the lamina.
  • Our analyses established subnuclear genome compartmentalization as a key regulator of bivalency.
Frontiers - Health22 Jul 2026
AIEarly lymphocyte recovery predicts cardiovascular events and mortality in immune checkpoint inhibitor-associated myocarditis: a retrospective cohort study (Fron

Early lymphocyte recovery predicts cardiovascular events and mortality in immune checkpoint inhibitor-associated myocarditis: a retrospective cohort study

Report examines whether early recovery of circulating lymphocytes after steroid start predicts cardiovascular events and death in patients with immunotherapy myocarditis.

Key takeaways
  • ICIAM is notable for early onset of 21–34 days after ICIs-treatment initiation.
  • Immune checkpoint inhibitors (ICIs) have profoundly improved outcomes across a wide range of cancer therapy.
  • Expanding usage of ICIs can cause a variety of immune-related adverse events (irAEs).
MoL Event Pick
MedTech World Asia | Hong Kong 2026 (Hong Kong, Hong Kong)

MedTech World Asia | Hong Kong 2026

26. AUG 2026 - 28. AUG 2026 - Hong Kong, Hong KongSummit

Hong Kong summit connecting MedTech and HealthTech leaders, startups, investors, hospital executives, regulators and innovators across APAC healthcare innovation.

Nature - Biotechnology22 Jul 2026
Precise DNA base editing using AlphaFold3-based contact modelling (Nature - Biotechnology)

Precise DNA base editing using AlphaFold3-based contact modelling

Describes ContactSeek, an AlphaFold3 contact-probability framework that pinpoints specificity-determining residues to improve base editor precision.

Key takeaways
  • Current strategies are constrained by activity-specificity trade-offs, high labour intensity and low success rates 3 , 4.
  • ContactSeek can also be applied modularly and identified key residues in the TadA8e deaminase.
  • Achieving high specificity in biochemical transformations is crucial for research and therapeutics.
Nature - Main22 Jul 2026
AIElectronic-resonance enhanced molecule for perovskite solar cells - Nature (Nature - Main)

Electronic-resonance enhanced molecule for perovskite solar cells - Nature

Perovskite solar-cell research article presenting a molecular-design strategy using a resonant self-assembled monolayer to improve interfacial anchoring and device performance.

Key takeaways
  • Donor–acceptor–donor resonant self-assembled monolayer increases negative charge density at the anchoring group.
  • Devices using the resonant SAM achieved high certified efficiencies.
  • Perovskite devices with the resonant SAM showed exceptional operational stability.