Survey of how existing clinical trial methylation datasets reveal which epigenetic clocks respond to longevity interventions and why.
Key Takeaways
- Curated TranslAGE database pooled 51 longitudinal interventional studies for consistent DNAm analysis
- Clocks trained on mortality or pace-of-aging measures showed the strongest and most consistent responses
- Pharmacological and lifestyle interventions drove the largest DNAm biomarker changes across studies