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Thirty-Five Years of Evolving Inflammatory Paradigms in Sepsis (1991–2025): A Comprehensive Mapping of Immune Dysregulation Research, Anti-Inflammatory Targets, and Translational Barriers

Source: Frontiers - Health • Published: 04 Sept 2026, 00:00

Thirty-Five Years of Evolving Inflammatory Paradigms in Sepsis (1991–2025): A Comprehensive Mapping of Immune Dysregulation Research, Anti-Inflammatory Targets, and Translational Barriers

A temporal, computational review maps 1991–2025 sepsis inflammatory research shifts, trending from broad cytokine focus to targeted immune mechanism exploration.

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  • Were retrieved from PubMed and the Web of Science Core Collection
  • Co-cited references were graded by Oxford Centre for Evidence-Based Medicine (OCEBM)
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