Senescence-focused review explaining what readers will learn about therapies aimed at reducing senescent cells to address age-related chronic lung disease and therapeutic approaches.
Key Takeaways
- Accumulation of senescent cells drives chronic lung inflammation
- Senolytic therapies that remove senescent cells have reversed disease phenotypes in animal pulmonary fibrosis models
- Clinical human data are limited but suggest senolytics may help idiopathic pulmonary fibrosis