Summarized by Masters of Longevity from Frontiers - Health.
A biodegradable microparticle system co-delivers combinatorial immunomodulators and antigen to stabilize tolerogenic dendritic cells and boost antigen-specific regulatory T cells.
Key Takeaways
- PLGA microparticles co-loaded with R848, CEP-33779, and ovalbumin released cargo intracellularly for up to 30 days.
- Dendritic cells that phagocytosed these particles showed increased PD-L1 and IL-10 and resisted inflammatory reprogramming.
- Adoptively transferred particle-treated DCs persisted in draining lymph nodes up to seven days and induced antigen-specific Foxp3+ Tregs.
