Research readers will open a structural biology article exploring how non-neutralizing antibodies bind a viral nucleocapsid and what that reveals about protective mechanisms.
Key Takeaways
- Nine monoclonal antibodies identified four distinct antigenic sites on the nucleocapsid protein
- Most potent antibody, 9D5, showed broad-spectrum protective characteristics supported by X-ray structures
- Antibody-mediated protection varied in vivo and was independent of head or stalk epitope location