Examines how senescent microglia secrete a soluble Notch ligand that impairs oligodendrocytes and neuronal function in aging brains.
Key Takeaways
- Senescent microglia with shortened telomeres secrete increased soluble DLK1 into cerebrospinal fluid
- Elevated sDLK1 in vivo caused hypomyelination and blocked oligodendrocyte lineage progression
- SDLK1 impaired oligodendrocyte maturation and altered calcium signaling in human iPSC-derived neurons