Summarized by Masters of Longevity from Science Daily - Health & Medicine.
Researchers report large epigenetic and 3D genome reorganizations in the aging human hippocampus, with major cellular changes emerging in midlife between about ages fifty and seventy-five.
Key Takeaways
- The study found a major shift in hippocampal immune cell composition between about ages 50 and 75, with original immune cells declining and more inflammatory cells rising.
- Cells that support the blood-brain barrier showed age-associated weakening across the hippocampus.
- Widespread deterioration occurred in the three-dimensional organization of the hippocampal genome during aging.
