Macrophage metabolic reprogramming in fatty liver disease — a review article guiding readers through mechanisms, regulatory circuits, and therapeutic research directions.
Key Takeaways
- Macrophage metabolic reprogramming is increasingly recognized as an important contributor to disease progression
- This review maps the metabolic circuits driving macrophage-mediated inflammation in MASLD
- IRG1-itaconate axis exhibits a dynamic U-shaped trajectory across MASLD stages