Summarized by Masters of Longevity from Nature - Biotechnology.
CAR-targeting microparticle technology that programs repeated stimulation to drive prolonged, functional ex vivo expansion of human CAR T cells.
Key Takeaways
- Programmable DNA-scaffolded PLGA microparticles repeatedly expanded human CD8+ CAR T cells for over 100 days.
- CAREp stimulation achieved up to 10^18-fold cumulative expansion and outperformed tumor-cell and CD3/CD28-Dynabead stimulation.
- Expanded CAR T cells retained effector function, mitochondrial fitness, delayed exhaustion, and transient telomerase activation.
