Reports a targeted screen identifying genes that enable adult PV interneuron plasticity and tests whether restoring one gene rescues circuitry, seizures and cognition.
Key Takeaways
- Feedforward inhibition of CA3/CA2 PNs mediated by PV INs dictates their spiking
- Here, these properties are collectively referred to as experience-dependent PV IN plasticity
- This process subsequently leads to increased feedforward inhibition in DG–CA3/CA2 circuits 9