Reports how rhythmic patterned light during in vitro differentiation enhances structural and functional maturation of stem cell–derived human photoreceptors.
Key Takeaways
- Rhythmic 40 Hz light flicker increased formation of outer segment–like structures in retinal organoids
- Light stimulation shifted photoreceptor transcriptional programs toward more mature rod and cone states
- Stimulated organoids showed stronger downstream neuronal responsiveness and higher photoreceptor protein expression